Bacterial 7-dehydroxylation of cholic acid and allocholic acid
نویسندگان
چکیده
منابع مشابه
Bacterial 7-dehydroxylation of cholic acid and allocholic acid.
An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes). The growth of the organism was inhibited by neomycin, 10-20 micro g/ml. The existence of this organism affords a satisfactory explanation fo...
متن کاملMechanism of intestinal 7 alpha-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible side-product.
We previously reported that the 7 alpha-dehydroxylation of cholic acid appears to be carried out by a multi-step pathway in intestinal anaerobic bacteria both in vitro and in vivo. The pathway is hypothesized to involve an initial oxidation of the 3 alpha-hydroxy group and the introduction of a double bond at C4-C5 generating a 3-oxo-4-cholenoic bile acid intermediate. The loss of water generat...
متن کامل7~Dehydroxylat ion of cholic acid and chenodeoxycholic acid by Clostridium leptum
The rate of 7a-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum. The pH optimum for the 7a-dehydroxylation of both cholic and chenodeoxycholic acid was 6.5-7.0. Substrate saturation curves were observed for the 7a-dehydroxylation of cholic and chenodeoxycholic acid. However, cholic aci...
متن کاملCholic acid–quinoxaline (2/1)
In the title inclusion compound, 2C(24)H(40)O(5)·C(8)H(6)N(2), the unit cell contains two mol-ecules of cholic acid (3α,7α,12α-trihydr-oxy-5β-cholan-24-oic acid) and one mol-ecule of quinoxaline which implies disorder of the quinoxaline in the space group P2(1). The amphiphilic mol-ecules of cholic acid assemble, in an anti-parallel arrangement, via O-H⋯O hydrogen bonds, into typical corrugated...
متن کاملMicrobiological Degradation of Bile Acids RING A CLEAVAGE AND 7ac,12a-DEHYDROXYLATION OF CHOLIC ACID BY ARTHROBACTER SIMPLEX By
The metabolism of cholic acid by Arthrobacter 8implex was investigated. This organism effected both ring A cleavage and elimination of the hydroxyl groups at C-7 and C-12 and gave a new metabolite, (4R)-4-[4a-(2-carboxyethyl)-3aachexahydro-7a#-methyl-5-oxoindan-Il-yl]valeric acid, which was isolated and identified through its partial synthesis. A degradative pathway of cholic acid into this met...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1969
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)43070-6